kilativ (kilativ) wrote,

Витамин Д и коронавирус

Вот пишут, что теоретически витаним Д должен блокировать белок Ковида и тем самым предотвращать инфекцию. Интересно, что существуют косвенные доказательства, что люди с пониженным содержанием витамина Д в крови хуже переносят ковидиоз. Заодно ивермектин проверили - но он не только малярию давит, но и известен тем, что подавляет вирус СПИДа, так что тут ничего интересного не наблюдается.

Vitamin D is known to be protective against acute respiratory distress syndrome (ARDS), pneumonia and cytokine storm. Recently it has been used as a repurposed drug for the treatment of H5N1 virus-induced lung injury. Circumstantial evidences indicate that people with low level of vitamin D are more susceptible to SARS-CoV-2. Although, vitamin D was suggested to interfere with viral replication, its interaction with any SARS-CoV-2 protein is unexplored yet. Beside this, ivermectin, a well-known anti-parasitic agent, exhibits potent anti-viral activities in vitro against viruses such as HIV-1 and dengue. Very recently, ivermectin has been found to reduce viral load of SARS-CoV-2 in vitro. We have analyzed available structures of SARS-CoV-2 proteins to identify probable binding partner(s) of vitamin D and ivermectin through knowledge-based docking studies and figured out possible implication of their binding in SARS-CoV-2 infection. Our observations suggest that the non-structural protein nsp7 possesses a potential site to house 25-hydroxyvitamin D3 (VDY) or the active form of Vitamin D, calcitrol.
Tags: наука, эпидемия

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