kilativ (kilativ) wrote,
kilativ
kilativ

Почему нельзя использовать просроченные лекарства

Poor-quality medicines undermine the treatment of infectious diseases such as tuberculosis, which requires months of treatment with rifampicin and other drugs. Rifampicin resistance is a critical concern for tuberculosis treatment. While sub-therapeutic doses of medicine are known to select for antibiotic resistance, the effect of drug degradation products on the evolution of resistance is unknown. Here, we demonstrate that substandard drugs that contain degraded active pharmaceutical ingredients select for gene alterations that confer resistance to standard drugs.
Отсюда

Если коротко - продукты распада антибиотика ведут к селекции штаммов устойчивых к функциональному антибиотику. На примере кишечной палочки и микобактерии.
Tags: научные новости
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